5-Year Impact Factor: 0.9
Volume 35, 12 Issues, 2025

Journal of College of Physicians and Surgeons Pakistan (JCPSP), is an open access, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.


The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.


Important Announcement for Trainees

"A companion journal of JCPSP (the official journal of CPSP) has been launched by the name of JCPSP Postgraduate (JCPSP PG). Submissions to JCPSP PG will be open from March 01, 2025"
For more details, Please visit https://jcpsppg.pk/.

Latest Articles
Volume 35 | Issue 6 | June 2025
Integrating Artificial Intelligence for Patient Safety in Pakistan: Opportunities, Challenges, and Lessons from Low- and Middle-Income Countries

By Sonia Ijaz Haider


The Effect of Magnesium Sulfate Infusion on Postoperative Opioid Consumption in Abdominal Hysterectomy: A Randomised, Double-Blind Trial

By Ilke Tamdogan, Dilek Yeniay, Esra Turunc, Fatma Alkan Bayburt, Sadettin Oguzhan Tutar

ABSTRACT Objective: To assess the impact of magnesium sulfate infusion on total opioid consumption following abdominal hysterectomy in a clinical setting. Study Design: Controlled, randomised, prospective, and double-blind trial. Place and Duration of the Study: Department of Gynaecology, Giresun Gy...

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Vitamin C as a Serum Uric Acid Lowering Agent in Hyperuricaemia

By Iqra Siddiqui, Moosa Khan, Faiza Rehman, Maleeha Abbas, Shahnawaz Jamali

ABSTRACT Objective: To assess the impact of Vitamin C supplementation compared to Allopurinol therapy on the modulation of serum uric acid levels in individuals diagnosed with hyperuricaemia. Study Design: A comparative analytical study. Place and Duration of the Study: Department of Pharmacology an...

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Utility of Dermoscopy and Interpretation of Dermoscopic Findings in Stable and Progressing Lesions of Vitiligo

By Sara Shafqat, Atiya Rahman, Zarin Manzoor, Shakila Junaid, Sidra Anwer, Janta Kumari

ABSTRACT Objective: To identify the various dermoscopic patterns present in vitiligo and its predictive value in determining the stability of the disease. Study Design: Cross-sectional study. Place and Duration of the Study: Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan, from Octo...

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Diagnostic Utility of Sonography and Magnetic Resonance Imaging in Evaluating Placenta Previa and Its Variants Using Intraoperative Findings as the Gold Standard

By Izza Shahid, Nadeem Ibrahim, Sadaf Shafique, Zunaira Zulfiqar

ABSTRACT Objective: To evaluate the diagnostic utility of ultrasonography and magnetic resonance imaging (MRI) for the diagnosis of placenta previa (PP) with accurate grading, keeping peroperative findings as the gold standard. Study Design: A cross-sectional study. Place and Duration of the Study:...

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Outcomes Between Fresh Embryo and First Frozen-Thawed Embryo Transfer in Donor Sperm In-Vitro Fertilisation

By Jiayao Chen, Zhiping Zhang, Wenjing Shi, Qin Yan, Shimin Wang, Xueqing Wu

ABSTRACT Objective: To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors. Study Design: Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children’s Hospit...

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A New Metric Classification System for Surgical Management of Retrosternal Goitres

By Hamid Mukhtar, Hira Zahid, Imran Mohib Khan, Saad Siddiqui, Bushra Haider, Shehzad Saeedullah

ABSTRACT Objective: To introduce a new metric classification system based on preoperative CT scans in the management of retrosternal thyroid pathologies. Study Design: Descriptive study. Place and Duration of the Study: Department of Otolaryngology, Northwest General Hospital and Research Centre, Pe...


Factors Associated with Ischaemic Stroke Development Despite Oral Anticoagulant Therapy in Patients with Non-Valvular Atrial Fibrillation

By Emre Ozdemir, Muhammed Mucahit Tiryaki, Zeynep Emren, Ozgen Safak, Enise Tiryaki, Aysen Suzen Ekinci

ABSTRACT Objective: To evaluate the effectiveness of the most popular risk scores (CHADS2, CHA2DS2-VASc, and ATRIA scores) in predicting stroke events in patients with non-valvular atrial fibrillation (NVAF) who were already receiving oral anticoagulant therapy (OAT). Study Design: An observational ...

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Role of Low Molecular Weight Heparin in Unexplained Recurrent Pregnancy Loss

By Rashida Parveen, Hajra Sultana, Aisha Siddiqa

ABSTRACT Objective: To evaluate the effectiveness of low molecular weight heparin (LMWH) in unexplained recurrent pregnancy loss (URPL). Study Design: Open-labelled, single-centre, randomised controlled trial. Place and Duration of the Study: Department of Obstetrics and Gynaecology, DG Khan Hospita...


FOXQ1 Suppressing Apoptosis in Colorectal Cancer Cells by P53 Deacetylation

By Guisong Yang, Huanjie Chen, Xiaolei Ma, Fugang Wang, Guiliang Ma, Hong Qi

ABSTRACT Objective: To investigate the impact of Forkhead box Q1 (FOXQ1) expression on platinum-based chemoresistance in colorectal cancer (CRC) cells, and to examine the regulatory function of FOXQ1 on Sirtuin 1 (SIRT1) protein expression and P53 protein deacetylation levels during the DNA damage r...

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Role of Combined MPFL Reconstruction and Lateral Retinacular Release in Lateral Patellar Instability

By Muhammad Usama, Hafiz Umair Hussain, Faraz Ahmad Khan, Bilal Zaib, Abid Ullah, Muhammad Basharat

ABSTRACT Objective: To evaluate the efficacy of the combined medial patellofemoral ligament (MPFL) and reconstruction release in lateral patellar instability in terms of radiological and functional outcomes following the procedure. Study Design: A retrospective observational study. Place and Durat...

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TFF3 as a Potential Prognostic Biomarker in Myelodysplastic Syndrome and Acute Myeloid Leukaemia

By Huali Hu, Fahua Deng, Siqi Wang, Hai Huang, Tingting Lu, Sixi Wei

ABSTRACT Objective: To explore and validate the biomarker trefoil factor 3 (TFF3) of immune infiltration in myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Study Design: Descriptive research. Place and Duration of the Study: Center for Clinical Laboratories, The Affiliated Hospital...

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Ultrasonic Radiomics Utilised to Predict Lateral Neck Lymph-Node Metastasis in Papillary Thyroid Carcinoma

By Xi Cai, Sichen Chen, Yan Ding, Fengsheng Zhou, Yu Zhang

ABSTRACT Objective: To investigate the clinical significance of preoperative prediction for detecting metastasis in lateral neck lymph nodes (LNLN) among patients diagnosed with papillary thyroid carcinoma (PTC). Study Design: Descriptive study. Place and Duration of the Study: Department of Medical...

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Extracorporeal Shock Wave Therapy in Shoulder Rehabilitation: Unlocking Motion and Reducing Post-Surgical Pain

By He-Bei He, Min-Cong Wang, Yong Hu, Cheng-Long Pan

ABSTRACT Objective: To evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) in improving pain, range of movement, and functional outcomes in patients with shoulder stiffness following rotator-cuff repair. Study Design: Descriptive study. Place and Duration of the Study: Department ...

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Effectiveness of Nicorandil in Heart Failure: A Meta-Analysis

By Tongge Mu, Kaixuan Tang, Yan Sun

ABSTRACT This meta-analysis aims to evaluate the effectiveness of nicorandil in treating heart failure by synthesising evidence from diverse studies. The study period spanned from 12/01/2023 to 28/02/2024. Observational and randomised controlled trials have been conducted to study the cardiovascular...


Abnormal Brain Function in Systemic Lupus Erythematosus: A Meta-Analysis of Resting-State Functional Magnetic Resonance Imaging

By Xi Sun, Dongmei Fu, Yuting Mao, Zuanfang Li, Yinghong Lin, Jiaqiu Lin

ABSTRACT This meta-analysis investigated the neurophysiological underpinnings of systemic lupus erythematosus (SLE) by examining resting-state functional magnetic resonance imaging (rs-fMRI) profiles of SLE patients in comparison to healthy controls. Rs-fMRI studies up to November 10, 2022 were extr...

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Comparison of the Combination of Interscalene Block and Superficial Cervical Block Anaesthesia with Interscalene Block Anaesthesia in Shoulder Surgery Operations

By Abdulhakim Sengel, Selcuk Secilmis, Evren Buyukfirat, Nuray Altay, Veysi Yazar, Mehmet Baki Bilsel

ABSTRACT Objective: To compare shoulder surgery patients who received interscalene nerve block (INB) and superficial cervical block (SCB) anaesthesia with those who received only INB anaesthesia. Study Design: Observational study. Place and Duration of the Study: Department of Anaesthesiology and ...


Comparison of Success Rate of Direct Versus Indirect Sinus Lifting Techniques for Vertical Bone Augmentation in Patients with Maxillary Dental Implants

By Syed Ammar Yasir, Muhammad Ishaq, Sameen Naweed, Syed Junaid Hussain Bukhari, Tariq Mahmood, Muhammad Arham

ABSTRACT Objective: To compare direct and indirect sinus lifting techniques in patients getting implants in the maxillary molar region for parameters such as postoperative pain, swelling, gingival inflammation, implant stability, and patient comfort. Study Design: Analytical study. Place and D...


Clinical Outcomes and Long-Term Effects of Consolidative Radiotherapy in Paediatric Hodgkin's Lymphoma

By Syed Muhammad Jawad Zaidi, Rabia Muhammad Wali, Naila Inayat, Sadia Anjum

ABSTRACT Objective: To evaluate the long-term effects and disease outcomes of consolidative radiotherapy in paediatric Hodgkin’s lymphoma (PHL). Study Design: Descriptive study. Place and Duration of the Study: Department of Paediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Rese...


Preliminary Survey Report of Eye Cancers in Pakistan

By Tayyab Afghani, Haroon Awan, Asad Aslam Khan

ABSTRACT Objective: To estimate the magnitude of eye cancer and its annual frequency, extrapolated from major eye care centres of the country. Study Design: Observational study. Place and Duration of the Study: Data were obtained from ten dedicated eye care institutions of three provinces of Pakista...


The Impact of IV Labetalol on Cardiotocographic Changes in Severe Preeclampsia

By Samina Aliya Sabir, Farnaz Zahoor, Ghulam Abbas

ABSTRACT Objective: To evaluate the impact of intravenous (IV) labetalol on cardiotocographic (CTG) findings in patients with severe preeclampsia and to determine its association, if any, with emergency caesarean section indications. Study Design: Descriptive case series. Place and Duration of the S...

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An Overview of Generative Artificial Intelligence in Medical Education

By Shilu Wang, Rongqing Geng, Rongguang Xu

ABSTRACT The application of generative artificial intelligence (GAI) in medical education and practice has garnered increasing attention, particularly its significant potential to enhance personalised learning and clinical training. This viewpoint explores the integration of GAI into medical educat...


The Association Between Facial Ageing and Bone Mineral Density: A Mendelian Randomisation Study

By Yabo Wang, Chao Zhen, Ziyu Wang, Lu Zhang, Yunzhen Chen

ABSTRACT This article aimed to assess the causative association between facial ageing and bone mineral density (BMD) using Mendelian randomisation (MR). In this observational study, single-nucleotide polymorphisms (SNPs) linked to facial ageing and four different body regions, including total minera...


Correlation of Peripheral Blood CD4/CD8 Ratio with Efficacy and Prognosis in Patients with Non-Small Cell Lung Cancer Receiving PD-1/PD-L1 Inhibitors

By Guo-Xiang Li, Qi-Ming Zheng, Yuan-Yuan Li, Ye-Peng Wang, Min Zhang, Zhi-Gang Sun

ABSTRACT The aim of this study was to investigate the predictive role of the peripheral blood CD4/CD8 ratio in patients with non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors therapy. Cochrane, Embase, Medline, PubMed, and Web of Science were searched until November 2023. Data we...


Comment on Ozgungor
et al.’s “Albumin Levels as Prognostic Markers in ICU Mortality”

By Tianchen Lin, Jiannong Wu


Hashimoto's Encephalopathy Co-Occurring with Graves' Disease in a Paediatric Patient: Efficacy of Early Plasma Exchange

By Yan Wang, Peisen Ruan, Hehe Chen


Accelerated Development of Brucellar Spondylitis after Self-Modification of Treatment

By Bo Liu, Wendong Xie, Zhiqi Zhang


Bilateral Medial Medullary Infarction: A Rare and Devastating Stroke Subtype

By Weiwei Gao, Lijuan Cai, Renjing Zhu


Neurilemmoma of the Seminal Vesicle: An Unexpected Rare Case During the Treatment of Liver Abscess

By Mingyang He, Junzi Liu, Qiyu Liu