5-Year Impact Factor: 0.9
Volume 35, 12 Issues, 2025

Journal of College of Physicians and Surgeons Pakistan (JCPSP), is an open access, peer reviewed monthly biomedical journal of the country published regularly since 1991. College of Physicians and Surgeons Pakistan is the parent body of this Journal.


The College of Physicians and Surgeons of Pakistan (CPSP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide credits to educational activities.

CPSP designates '3 AMA PRA Category 1 Credits' for review of the manuscript of an original study.


Latest Articles
Volume 35 | Issue 11 | November 2025
Immunotherapy: Imaging Challenges and Advances in Response Assessment

By Maseeh Uz Zaman, Nosheen Fatima


The Efficacy of Ibuprofen for Postoperative Pain Following Laparoscopic Cholecystectomy: A Randomised Controlled Study

By Azime Bulut, Fatma Alkan Bayburt, Ilke Tamdogan

ABSTRACT Objective: To compare the effects of intravenous (IV) ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy. Study Design: Randomised-controlled study. Place and Duration of the Study: Department of Anaesthesiology and Reanimation,...


Efficacy and Safety of Methotrexate Administered by Oral and Subcutaneous Routes in Patients with Severe Psoriasis

By Mehwish Amin, Kulsoom Farhat, Aisha Akhtar, Sakina Sadiq Malik

ABSTRACT Objective: To compare the efficacy and safety of oral and subcutaneous (SC) routes of methotrexate (MTX) administration in patients with severe psoriasis in terms of the time taken to attain a Physician Global Assessment (PGA) score of 0 or 1. Study Design: Single-blinded randomised control...

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Face and Content Validity Between DaVinci and CMR Robotic Simulator among General Surgical Faculty

By Shahriyar Ghazanfar, Yumnah Safdar, Erum Kazim, Rabia Feroz, Aftab Ahmed Leghari, Mohammad Faisal Ibrahim

ABSTRACT Objective: To compare the face and content validity of two robotic surgery simulators—the DaVinci Skills Simulator (dVSS) and the CMR Versius Simulator—among surgeons with varying levels of experience, to guide simulation-based training programmes. Study Design: Descriptive anal...


Detection of Schistosoma Eggs Using an AI-Based Deep Learning Model on Urinary Bladder Histopathology Images

By Mahin Shams, Aqsa Abu Bakar, Talat Zehra, Shamsu Bello, Salma Parween, Asad Jafri

ABSTRACT Objective: To assess the accuracy and clinical applicability of YOLO-based segmentation models for detecting Schistosoma eggs in urinary bladder histopathology slide images, focusing on both bounding box and mask segmentation tasks. Study Design: A descriptive, cross-sectional study. Place ...

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Early-Term Results of Endovenous Saphenous Vein Radiofrequency Ablation Combination with Trans-
sheath Ultrasound-Guided Foam Sclerotherapy

By Sonay Oguz

ABSTRACT Objective: To determine the early success rate in cases of great saphenous vein insufficiency treated with radiofrequency ablation (RFA) and combined transsheath ultrasonography-guided foam sclerotherapy (RFA+ST). Study Design: Descriptive study. Place and Duration of the Study: Department ...


Comparative Accuracy of Different Machine Learning Models in Predicting Early Neurological Deterioration after Intravenous rt‑PA Thrombolysis in Patients with Acute Ischaemic Stroke

By Yi  Ba, Xiaolin Xu, Hong’an Gao, Chengguang Song

ABSTRACT Objective: To compare six machine learning models for predicting early neurological deterioration (END) after intravenous rt-PA thrombolysis in acute ischaemic stroke, and to develop an interpretable clinical tool. Study Design: Observational study. Place and Duration of the Study: Departme...


Early Versus Delayed Decompression in Cauda Equina Syndrome: Neurological and Functional Outcomes

By Gohar Ali, Waseem Sajjad, Muhammad Zeeshan Ali, Shehzad Sadbar, Muhammad Naveed Khan, Muhammad Kamran

ABSTRACT Objective: To compare the neurological and functional outcomes of early versus delayed surgical decompression in patients with cauda equina syndrome (CES). Study Design: Descriptive study. Place and Duration of the Study: Department of Neurosurgery, Medical Teaching Institution, Mardan Medi...


Neutrophils and IL-12 Levels in Female Patients with Unexplained Infertility

By Basak Unver Koluman, Esin Avci, Semin Melahat Fenkci, Ibrahim Veysel Fenkci, Aysenur Akkoc, Hande Senol

ABSTRACT Objective: To evaluate the levels of interleukin-12 (IL-12), a critical cytokine for NK cells, and hemogram parameters in infertile women with unknown causes. Study Design: Descriptive study. Place and Duration of the Study: Department of Gynaecology and Obstetrics, Medical Facul...


Frequency of Subclinical Hypothyroidism in Subfertile Females and the Effect of Thyroxine Replacement

By Shehla Arif, Farah Deeba Nasrullah, Riffat Jaleel, Farah Shabi Ul Hasnain, Aman Ullah Abbasi

ABSTRACT Objective: To determine the frequency of subclinical hypothyroidism (SCH) and autoimmune thyroid disease (ATD), assess dominant follicular formation and conception rates after thyroxine replacement, and evaluate the association between SCH and ATD with conception among subfertile females. S...


Factors Associated with Survival Outcomes in Ovarian Cancer Patients in Karachi, Pakistan: Results from a Single-Institution Cancer Registry

By Uzma Shamsi, Namra Usman, Azmeena Tajuddin, Uzma Chishti

ABSTRACT Objective: To evaluate survival outcomes and identify sociodemographic and clinicopathological factors associated with survival among women diagnosed with ovarian cancer (OC) in Karachi, Pakistan. Study Design: Retrospective cohort study. Place and Duration of the Study: The Aga Khan Unive...


Atypical Presentation of Hepatitis A in Children

By Irum Aslam, Sundus Irshad, Muhammad Abu Talib, Ghazi Khosa, Aslam Sheikh, Nagina Shahzadi

ABSTRACT Objective: To determine the frequency of atypical presentation of hepatitis A virus (HAV) infection in children. Study Design: A cross-sectional study. Place and Duration of the Study: Department of Paediatric Gastroenterology, Hepatology and Nutrition, The Children’s Hospital and the...

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Neck Muscle Stiffness Measured by Shear Wave Elastography in Patients with Cervicogenic Dizziness:
A Case-Control Study

By Yaser Said Cetin, Semra Agirbas, Mesut Ozgokce

ABSTRACT Objective: To evaluate the neck muscle stiffness in patients with cervicogenic dizziness (CGD) using shear wave elastography (SWE). Study Design: A case-control study. Place and Duration of the Study: Department of Otorhinolaryngology, Van Yuzuncu Yil University, Van, Turkiye, from 2023 to ...


Screening and Prenatal Diagnosis of Spinal Muscular Atrophy among Reproductive-Age Individuals from the Hubei Region

By Jieping Song, Hui Li, Chengcheng Zhang, Yufei Jiang, Meiqi Yi, Mengxin Shen

ABSTRACT Objective: To conduct carrier screening for spinal muscular atrophy (SMA) among individuals of childbearing age in the Hubei region, identify the carrier frequency, and provide a relevant basis and reference for prenatal diagnosis. Study Design: An observational study. Place and Duration of...


Efficacy and Safety of Saccharomyces Boulardii with Standard Quadruple Therapy for Eradication of Helicobacter Pylori in Adults: Meta-Analysis

By Fengzhen Ma, Heyin Huang, Kanglin Tian, Wei Wang

ABSTRACT Helicobacter pylori is a class I carcinogen, strongly associated with gastric cancer, gastric ulcers, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Helicobacter pylori (H. pylori) infection necessitates effective eradication strategies. This study evaluated S...


Comparative Efficacy of Venlafaxine and Other Medications in Migraine: A Meta-Analysis with Trial Sequential Analysis

By Ju Gao, Guang Ming Xia, Xiang Bo Wu, Yu Tian, Guang Lin Wang, Jinhua Wang

ABSTRACT This meta-analysis with trial sequential analysis (TSA) evaluated the efficacy of venlafaxine in migraine prevention through database searches from inception to 1st November 2024. A total of eight studies involving 582 patients were included. Results demonstrated venlafaxine's superior...


Comparison of Flipped Classroom and Large-Group Interactive Strategies for Teaching the Basis of Screening to MBBS Students

By Shezadi Sabah Imran, Khola Waheed Khan, Laiba Khan, Musarat Ramzan, Sadia Nadeem, Robina Mushtaq

ABSTRACT Objective: To compare the effectiveness of a flipped classroom model and a large group interactive session (LGIS) method to teach the basis of screening to fourth-year MBBS students. Study Design: Quasi-experimental study. Place and Duration of the Study: Department of Community Medicine, ...


A Deep Learning Approach for Detecting Periapical Lesions on Panoramic Radiographic Images

By Mert Yagiz Pekiner, Hakan Yulek, Ayse Gul Oner Talmac, Gaye Keser, Filiz Namdar Pekiner, Ibrahim Sevki Bayrakdar

ABSTRACT Objective: To assess the performance of a deep learning method for detecting the segmentation of periapical lesions on dental panoramic radiographs. Study Design: Observational study. Place and Duration of the Study: Faculty of Dentistry, Van Yuzuncu Yil University, Van, Turkiye, from ...


Clinical Utility of Multiplex PCR for Managing Community-Acquired Pneumonia in Diabetic and Non-Diabetic Patients

By Orhan Dalkilic, Selami Aydin, Bekir Sami Uyanik, Suveyda Gozukucuk

ABSTRACT Objective: To compare the positivity rates of pathogens detected in diabetic and non-diabetic pneumonia cases, to assess the role of multiplex respiratory polymerase chain reaction (PCR) testing in diagnosis, and to compare inflammatory parameters between the two groups. Study Design: Obser...

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Sarcopenia in Chronic Obstructive Pulmonary Disease

By Sukriye Gundogdu, Halil Ibrahim Yakar, Handan Inonu Koseoglu, Ahmet Cemal Pazarli, Gokhan Aykun

ABSTRACT  Objective: To investigate the frequency of sarcopenia in patients with chronic obstructive pulmonary disease (COPD) and in the Control group, and to compare the 6-minute walk test (6MWT), handgrip strength (HGS) measured by a dynamometer, pulmonary function test (PFT) parameters, and ...


Comparison of Open Mesh Repair and Laparoscopic (TEP/TAPP) Techniques in Primary Unilateral Inguinal Hernia Repair

By Ali Sapmaz, Serhan Yilmaz, Cenk Ozkan, Canbert Celik, Hatice Telci, Eda Sahingoz

ABSTRACT Objective: To evaluate the safety and effectiveness of treatment for inguinal hernia and to compare the short- and long-term outcomes of open mesh repair (OMR) and laparoscopic total extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) techniques in primary unilateral inguinal her...


DeepSeek-R1 in Clinical Medicine: Advancing AI-Driven Diagnostics, Decision Support and Medical Education

By Yuhui Chen, Shousen Wang

ABSTRACT DeepSeek, a rising artificial intelligence (AI) company in Hangzhou, China, introduced DeepSeek-R1, an advanced reasoning model that rivals top large language models such as GPT-4 and Gemini, while operating at significantly lower costs. Its innovative architecture, which includes multi-hea...


Comprehensive Evaluation of Peripheral Blood Count Parameters in Donor Deferral: Its Utility as a Quality Control Tool in Blood Banking

By Helen Mary Robert, Zunairah Mughal, Noman Anjum Rana, Intzar Ali, Sumaira Ilyas, Ayesha Wahid Mian

ABSTRACT This study assessed the role of peripheral blood counts in donor deferral and its utility as a quality control measure in blood banking. It was conducted retrospectively at the Department of Haematology, Combined Military Hospital, Lahore, Pakistan, from April 2023 to September 2023. The st...


The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus

By Saadiya Siddiqui, Ayesha Chatta, Faria Altaf

ABSTRACT This study aimed to evaluate the efficacy of 0.2% topical hyaluronic acid in the management of symptomatic oral lichen planus (OLP). This prospective interventional study was conducted at the Department of Dermatology, Services Institute of Medical Sciences / Services Hospital, Lahore, Paki...


Reducing Unnecessary Free Thyroid Hormone Testing

By Xuan Zhang, Guo-Ming Zhang


Unexpected Trio: Bisalbuminaemia and Autoimmune Haemolytic Anaemia Emerging in Monoclonal Gammopathy

By Muhammad Umer Naeem Effendi, Syed Bilal Hashmi, Hafsa Majid


A Case of Primary Vitreoretinal Lymphoma

By Chao Wang, Shuai Wu


Rupture of the Extensor Pollicis Longus Tendon Following Intramedullary Nailing for Radial Shaft Fracture

By Jiawei Li, Shaoke Wu


Carbamazepine Overdose Successfully Treated with Combined Resin Haemoperfusion and Continuous Venovenous Haemodiafiltration

By Wenbin Zhang, Xiaoyun Yang, Xiaohong Huang